Recent Publications: Associate Professor Michael Butcher, Alum Brett Aiello

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Aiello BR (YSU STEM alum), Iriarte-Diaz J, Blob RW, Butcher MT (YSU STEM associate professor), Carrano MT, Espinoza NR, Main RP, Ross CF. Tissue-level strain magnitude is encoded in tissue-level bone strain rate and cellular-level fluid flow rate. In press, Proceedings of the Royal Society B   (impact factor: 5.29)

The structural integrity of vertebrate bones is maintained via adaptive modeling in response to mechanical stimuli. Increased tissue-level strain magnitude and rate have both been identified as potent stimuli leading to increased bone formation. Using strain gauge data from tetrapod limb bones we identified strong correlations between strain rate and magnitude across clades employing diverse locomotor styles. The breadth of our sample suggests that this pattern is likely a common feature of tetrapod bone loading. This finding is consistent with the hypothesis that it might be encoded in fluid-flow rate at the cellular-level, facilitating bone adaptation via mechanotransduction.